El seminario titulado "Mecanismos moleculares que regulan la tolerancia en los linfocitos T. Relevancia para el desarrollo de inmunoterapia" será impartido por el Dr. Fernando Macian el próximo lunes 7 de septiembre de 2015 a partir de las 13.00 h. en el Salón de Actos del edificio del Instituto de Investigación Sanitaria INCLIVA.
Macian Lab (overview): The antigen receptors of T cells recognize not only antigens derived from pathogenic cells and organisms, but also self-antigens expressed on the body's own tissues. In healthy individuals, self-antigens do not elicit a significant immune response. Self-reactive lymphocytes are clonally eliminated during development and cells that survive this process are rendered tolerant in the periphery.
Two of the major of the mechanisms responsible for peripheral T cell tolerance are anergy, an intracellular process in which antigen receptors become uncoupled from their downstream signaling pathways, and regulatory T cells, a population of T cells with the ability to suppress activation of other T cells as well as B cells and dendritic cells. The biochemical pathways that cause inhibition of T cell responses in anergic or suppressed T cells are poorly understood. One of the goals of our lab is to study the molecular mechanisms responsible for the induction of tolerance in T cells
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